HSF1 and cardiac hypertrophy: The several main regulators of PPARα such as HSF-1, ATGL, RXRα, and ERRα were detected (Montaigne et al., 2021), the downregulation of which are associated with cardiac hypertrophy (Huss et al., 2007; Haemmerle et al., 2011; Zhu et al., 2014; Tian et al., 2020).