The Royal College of Obstetricians and Gynecologists (RCOG) defined low risk thrombophilia as heterozygous for factor V Leiden or prothrombin G20210A mutations; and high risk thrombophilia as antithrombin deficiency, protein C or S deficiency, compound or homozygous for low-risk thrombophilia (24). This evidence concerns the gene F2 and thrombophilia.