Given that gasdermins also play an indispensable role in the process of pyroptosis, we then evaluated their prognostic value in MIBC cases of TCGA-BLCA cohort, and found that expression of GSDMB, but not GSDMA, GSDMC, GSDMD or GSDME, was associated with overall survival, and OS and PFS of GSDMB-high group was significantly better than GSDMB-low group (Figure 2B and Supplementary Figures 2B, C). The gene discussed is GSDMD; the disease is bladder transitional cell carcinoma.