Similarly, NEU1 protein levels were increased in cardiomyocytes in the STZ mouse model of diabetic cardiomyopathy, and NEU1 silencing protected against STZ-induced cardiomyopathy and myocardial fibrosis, inflammation, and apoptosis through an AMPK-SIRT3 pathway (131). Here, NEU1 is linked to diabetic cardiomyopathy.