Mice deficient in NEU1 activity and fed a high fat diet (HFD) developed glucose intolerance and insulin resistance compared with mice expressing normal levels of NEU1, and HEK293 cells overexpressing both NEU1 and the insulin receptor kinase (IRK) exhibited increased IRK-NEU1 association and NEU1-mediated IRK desialylation (39). This evidence concerns the gene NEU1 and Insulin resistance.