Since HCP-LCE is expected to provide increased tumor-specificity compared to the bispecific antibody SEB7xICI2_H2 and the corresponding monospecific antibodies due to simultaneous binding of EGFR and PD-L1 at each Fab arm, cell binding experiments were performed on EGFR/PD-L1 double-positive A431 cells by flow cytometry. Here, CD274 is linked to neoplasm.