In this study, the clinical data of 181 patients in our hospital were retrospectively analyzed, and it was found that two groups of patients with anti-MNDAR encephalitis of different severity at admission had significant statistical differences in autonomic dysfunction, consciousness declination, ICU admission, WBC, CRP, neutrophil percentage, albumin, and NPAR. The gene discussed is CRP; the disease is Abnormal autonomic nervous system physiology.