CD163 and HIV-1 infection: Besides, the discovery reveals that acquired and innate immunity variations are independent of each other in senescence and HIV-1 infection, implying that a parallel but independent causal link may drive innate and acquired immunity variations in the process of HIV infection and explaining the involvement of monocyte immunity parameters, such as CXCL10 and sCD163, as well as acquired immunity parameters, in immunosenescence research (61).