ITGB2 and amyotrophic lateral sclerosis: In conclusion, the overexpression of DHRS4, and its synergistic DHRS3, may be primarily associated with the activation of the complement cascade in the immune system (C1QA, C1QB, C1QC, C3, and ITGB2), which may be a novel mechanism that induces spinal neurodegeneration in ALS.