Regarding EBV-positive T/NK cell LAHS patients, univariate analysis revealed lower ALT level, lower IL6 level, higher PT level, combined treatment of first anti-HLH regimen and subsequent anti-lymphoma regimen, achieving CR or PR were significantly related to improved OS (P=0.001, P=0.016, P=0.044, P=0.017, and P=0.013, respectively). Here, IL6 is linked to hemophagocytic syndrome.