Although body weight loss trends were comparable between two mouse groups, TNFR1/2-/- mice were highly susceptible to infection, showing earlier death (D7 in knockouts vs. D11 in WT mice, Figure 2A), significantly higher lethality rates (100% at D9 in knockouts vs. 75% until D20 in WT mice, Figure 2B), and significantly higher bacterial loads in the spleen and lungs than WT mice at D8 (p < 0.01, Figure 2C). The gene discussed is TNFRSF1A; the disease is infection.