Interestingly, neutrophils-PLTs aggregates increased in ND APL and IT APL compared to the control, including both undifferentiated neutrophils-PLTs (CD41+ counts in CD16- CD11b- population) and differentiated neutrophils-PLTs aggregates (CD16+ CD41+ events) (Figures 2E, F). This evidence concerns the gene ITGAM and acute promyelocytic leukemia.