The severity of the acute COVID-19 systemic disease according to the respiratory status was associated with CSF levels of 14-3-3 (ρ=0.689; p=0.018) and NfL (ρ=0.45; p=0.043), and serum levels of IL-18 (ρ=0.498; p=0.005), IL-1RA (ρ=0.487; p=0.025), IL-8 (ρ=0.367; p=0.014) and serum NfL (ρ=0.677; p<0.001). This evidence concerns the gene NEFL and COVID-19.