In conclusion, this study demonstrated the role of CD34+ hfDSCs in HF regeneration through in vivo lineage tracing, which further demonstrated that β-catenin signaling determines the differentiation of CD34+ hfDSCs into DP cells through β-catenin knockout and stabilization, and regulates the transformation of hair cycle and HF senescence. The gene discussed is CD34; the disease is hydrops fetalis.