Therefore in this study, we used CD34CrePGR: mTmG:Ctnnb1tm1Mmt/+ (referred to as CD34:mTmG:β-catact) mice as a HF reconstitution model to stabilize β-catenin in CD34+ cells, and found that CD34+ hfDSCs with stabilized β-catenin accelerated their differentiation into DP and DS. Here, CD34 is linked to hydrops fetalis.