Similar to the “DNMT-miR-29” epigenetic circuit, negative feedback regulatory loops between “DNMT1-miR-148/152” in esophageal squamous cell carcinoma and “DNMT1-miR-126” in breast cancer have been reported (Liu, et al., 2015; Zhao, et al., 2011). Here, DNMT1 is linked to esophageal squamous cell carcinoma.