Similarly, E3 ubiquitin ligase S-phase kinase-associated protein 2(SKP2) also plays a role in ferroptosis: YAP (Yes-associated protein 1) is the only analogue of TAZ (a regulator of the Hippo pathway, which regulates ferroptosis in renal and ovarian cancer cells), which promotes the production of ROS by regulating the SKP2 thus aggravates ferroptosis. This evidence concerns the gene YAP1 and ovarian cancer.