In GEPIA database which contained the data from TCGA and Genotype-Tissue Expression project (GTEx), we found that the expression levels of MYO1B, MYO1G, MYO5A, MYO9B, and MYO10 were obviously increased in cancer tissues compared with normal tissues in HNSCC, whereas MYO5C was the only significantly downregulated MYO protein (Figure 1(b)). This evidence concerns the gene MYO5C and head and neck squamous cell carcinoma.