Taken together, the aforementioned details of MYO5C on expression, survival data, and diagnostic value, we considered that it may not be sufficient as a stable indicator of HNSCC; therefore, we mainly illustrate the effects and values of MYO1B, MYO5A, and MYO10 in the following studies. The gene discussed is MYO5A; the disease is head and neck squamous cell carcinoma.