Tropomyosin receptor kinases (TRKs) belong to the family of cell surface receptor tyrosine kinase (RTK) and are further classified into TRKA, TRKB and TRKC.68 Various studies reported that TRKs can mediate cell proliferation, metabolism, differentiation and apoptosis.69–71 The abnormal expression of TRK can lead to various types of human cancers.72–75. This evidence concerns the gene NTRK1 and cancer.