TERT and neoplasm: Molecular profiles, such as isocitrate dehydrogenase (IDH)-mutant, 1p19q co-deletion, the X-linked alpha-thalassemia mental retardation (ATRX)-mutant, Telomerase reverse transcriptase (TERT) promoter mutant, and O6-methylguanine–DNA methyltransferase (MGMT) promoter methylation, provide a microscopic view for predicting tumor biological behavior and patients’ outcomes.