FGA and hemorrhage: Jagiełła et al. (2014) reported that AA genotype of FGA Thr312Ala was correlated with a higher prevalence of ICH. The same FGA polymorphism has been reported to cause amino-acid substitution and influence clot structure and properties by facilitating factor XIII cross-linking of fibrin fibers (Standeven et al., 2003). It is assumed that FGA Thr312Ala variant could increase the risk of ICH involving the coagulation pathway, since the disturbance of blood coagulation contributes to the occurrence of hemorrhage.