APOE, GPX1, CR1, ITGAV, PRKCH, and 12q21.1 were identified to be associated with LICH, and most of them are involved in CAA-ICH, while ACE, COL4A2, 1q22, TIMP1, TIMP2, MMP2, MMP9, and TNF were found to be associated with DICH, and mainly by mediating the damage of vascular integrity, and the progression of hypertension and atherosclerosis. This evidence concerns the gene APOE and Hypertension.