In the study of heritability estimates on ICH, Devan et al. have identified that APOE loci and non-APOE loci (CR1 and hypertension-related genes) accounted for some inherited genetic contributions to ICH, with rates at 44, 72, and 51% for risk, admission hematoma volume, and 90-day mortality, respectively (Biffi et al., 2010, 2012; Falcone et al., 2012; Devan et al., 2013). This evidence concerns the gene APOE and hypertensive disorder.