The main functions of VEGF: (1) Specifically enhance the mitosis of vascular endothelial cells, stimulate the proliferation of vascular endothelial cells and promote neovascularization; (2) Improve the permeability of micro blood vessels, and provide nutrients for the growth of tumor cells and the establishment of capillary network through the extravasation of nutrients such as plasma macromolecules. This evidence concerns the gene VEGFA and neoplasm.