APP and early-onset autosomal dominant Alzheimer disease: The burst detection of author keywords showed that “interferon-gamma” burst from 1991 to 1999, “Cytokine” burst from 1991 to 2000, “Alzheimer’s disease” and “cell death” burst from 2001 to 2005, “in vivo” burst from 2004 to 2008, “amyloid precursor protein” burst from 2005 to 2013, “beta” burst from 2011 to 2017, “macrophage” burst from 2011 to 2019, “inflammation” burst from 2015 to 2017 (Figure 13).