It has been found that securinine stimulates apoptosis in p53 knockout colon cancer cells,20 as well as in human breast cancer MCF-7 cells,21 human promyelocytic leukemia cells HL-60,22 human promyelocytic leukemia cells K-562,23 HCT 116,20 SW480 (ref. 24 and 25) colon cancer cells, HeLa cervical cancer cells,26etc. The gene discussed is TP53; the disease is colonic neoplasm.