In this study, circ‐MTO1 was down‐regulated in gastric tumor tissue compared with adjacent tissue, which could be explained by that overexpression of circ‐MTO1 inhibited the proliferation of gastric cancer cells via multiple mechanisms such as regulating miR‐199a‐3p/PAWR axis, miR‐3200‐5p/PEBP1 axis, miR‐9/p21 axis, and Wnt/β‐catenin signaling pathway.19, 21, 22, 23. The gene discussed is MTO1; the disease is gastric neoplasm.