These results showed hypertrophic adipocytes are responsible for obesity-related increases in Wn5a levels in sera and that Wnt5a in obese adipose tissues functions as an autocrine or paracrine factor that inhibits the expansion of adipose tissues, which suggests hypertrophy/YAP/Wnt5a signaling constitutes a negative-feedback loop that prevents the overexpansion of adipose tissues. This evidence concerns the gene WNT5A and obesity disorder.