Furthermore, specific ablation of Wnt5a in adipocytes increased fat mass and glucose intolerance but did not downregulate the expressions of inflammatory cytokines in adipose tissues, which suggests that hypertrophy/YAP/Wnt5a signaling in adipocytes constitutes a negative feedback circuit that restrains the overexpansion of adipose tissues. The gene discussed is WNT5A; the disease is Glucose intolerance.