In conclusion, we built a TF-miRNA-mRNA regulatory network with an emphasis on the regulations of hub gene NCOA6 mediated by PPARA (miR-21-PPARA-NCOA6) to reveal a potential mechanism of dysregulated keratinocyte proliferation, differentiation, and migration in diabetic skin based on the enrichment analysis of T2DM-related gene modules detected by WGCNA. Here, PPARA is linked to type 2 diabetes mellitus.