However, as proof-of-principle we were able to establish that adoptive transfer of immature activated neutrophils isolated from BM of LPS-treated mice has antitumour activity in NASH-HCC and this effect was accompanied by remodelling of tumour immunity including the activation of cDC1 cells, elevated CD8+ T cell counts and induction of anti-tumoural Gzmb; these being changes that were also noted with AZD506/anti-PD1 therapy. This evidence concerns the gene GZMB and hepatocellular carcinoma.