This identifies CXCR2 as a neutrophil chemokine receptor that could be targeted to manipulate TANs in models of HCC-NASH.14 In humans, the CXCR2 ligands CXCL1 and CXCL8 were significantly upregulated in NASH-HCC compared with NASH (online supplemental figure 2G). Here, CXCL8 is linked to metabolic dysfunction-associated steatohepatitis.