We found significantly lower signal intensities of CD63 (*), of CD42a (****) positive serum-derived EVs comparing AML with CLL derived EVs and significantly lower signal intensities of CD63 (*), of CD42a (****) positive serum-derived EVs comparing ALL with CLL derived EVs when normalized to WBC counts (Fig. 5c). This evidence concerns the gene GP9 and B-cell chronic lymphocytic leukemia.