A significant positive correlation was found between serum-derived EV CD29 (integrin β1) (r = 0.56, p = 0.1, n = 8), CD41b (integrin αIIβ) (r = 0.34, p = 0.4, n = 8), CD49e (integrin α5) (r = 0.80, p = 0.01, n = 8) and IC leukemic cells in AML, ALL and CLL samples. Here, ITGA5 is linked to B-cell chronic lymphocytic leukemia.