We found significantly lower signal intensities of CD63 (*), of CD42a (****) positive serum-derived EVs comparing AML with CLL derived EVs and significantly lower signal intensities of CD63 (*), of CD42a (****) positive serum-derived EVs comparing ALL with CLL derived EVs when normalized to WBC counts (Fig. 5c). Here, CD63 is linked to acute lymphoblastic leukemia.