A low negative correlation between serum-derived EV CD11c (integrin αX or CR4) (r = -0.06, p = 0.8, n = 8) and IC leukemic cells (Fig. 6), and a significant positive correlation between serum-derived EV HLA-ABC (MHC-I) (r = 0.80, p = 0.01, n = 8) and HLA-DRDPDQ (MHC-II) expression (r = 0.49, p = 0.2, n = 8) and IC leukemic cells in AML, ALL, and CLL samples were found (Fig. 6). The gene discussed is CRIPTOP4; the disease is acute lymphoblastic leukemia.