ASCL1-low NEPC can be driven by other neuronal transcription factors such as NeuroD1, YAP1 or POU2F3 similar to what was observed in SCLC39,44–46 Building on the observation that ASCL1 induces rapid neurogenesis during normal neuron development47,48, neuronal differential in glioblastoma stem cell25 and neuroendocrine differentiation in lung cancer49 and induces NE markers in prostate cancer50,51, we found that ASCL1 induces neuroendocrine phenotype by directly regulating neuronal and stem cell programs. The gene discussed is POU2F3; the disease is glioblastoma.