Visualization of genomic loci from ChIPseq demonstrated direct regulation of both CSC genes including SOX2 (reported to be regulated by ASCL1, in small cell lung cancer (SCLC)27), NANOG and OCT4 (encode by POU5F1); and NE genes including CHGA, ENO2 (NSE), NCAM1, DLL1 (known ASCL1 target28) (Fig. 4e). The gene discussed is POU5F1; the disease is small cell lung carcinoma.