Interestingly, we find that brain-specific unannotated 3’UTRs were enriched for binding of RBPs already implicated in neurological disorders, such as TARDBP and RBFOX1. Furthermore, genes linked to unannotated brain-specific 3’UTRs were significantly enriched for those involved in synaptic function, and although not a significant enrichment, some were already associated with rare neurogenetic and adult-onset neurodegenerative disorders. This evidence concerns the gene TARDBP and nervous system disorder.