IFNGR1 and infectious disease: Human IFNGR1 gene deficiency has been associated with an increased susceptibility to certain infectious diseases in patients, such as mycobacterial infections.46, 47, 48 This raises questions about the systemic effects of DCA-siRNA from silencing IFNGR1. In our work, DCA-siRNA Ifngr1 show systemic silencing of mouse Ifngr1 in the liver, but not in the kidneys, spleen, muscle, or distal skin.