Dysregulation of IFN-γ signaling is associated with many inflammatory and autoimmune diseases,37,38,43 and modulation of IFN-γ signaling pathway using small molecule JAK inhibitors show encouraging results for treating some skin diseases.9, 10, [11], 12, 13 We hypothesize that targeting IFN-γ receptor may prove to be a viable and more specific strategy for modulating IFN-γ signaling. The gene discussed is IFNG; the disease is autoimmune disease.