CCL2 and amyotrophic lateral sclerosis: In the neurological context, the increased expression of MCP1 is usually associated with neurodegenerative/neuroinflammatory diseases,104, 105, 106 including ALS.107, 108, 109 Accordingly, in the spinal cord of SOD1G93A mice, we recorded a gradual increase in MCP1 levels as the disease progresses, characterized by a prominent expression by activated microglia at the advanced disease stage.