CCL2 and amyotrophic lateral sclerosis: In addition, although at 20 weeks a reduced NMJs denervation was still recorded upon MCP1 boosting, the lack of the myogenic response in association with the same extent of TA muscle atrophy compared to C57SOD1G93A scAAV9(empty)-treated mice indicated a gradual exhaustion of the elicited muscle pro-healing immune response in the hindlimbs of ALS mice as the disease progresses.