In contrast to other promoter mutation plasmids, the luciferase activity of the pGL3-ALDH2-NFYA-M1 was significantly decreased in NSCLC/PTX cells, which suggests that transcriptional activation of the ALDH2 promoter is dependent on NFYA (Fig. 3E and Fig. S4F). Here, ALDH2 is linked to non-small cell lung carcinoma.