Moreover, our previous studies reported that histone deacetylases (HDAC) and transcription factor retinoic X receptors (RXRs) cooperatively regulated HtrA1 (high temperature requirement factor serine peptidase 1) in cisplatin resistance, and targeting the HDAC/RXR/HtrA1 signaling pathway overcame the cisplatin resistance in NSCLC cells [19]. Here, HTRA1 is linked to non-small cell lung carcinoma.