To investigate whether this could serve as an exploitable vulnerability, we irradiated the primary murine NSCLC cell lines KP and KPP in the presence or absence of PI-103, a potent PI3K/AKT and mTOR inhibitor, that also interferes with DNA-PK (Fig. 4A and Additional file 1: Fig. S4A, B and [37]). Here, PRKDC is linked to non-small cell lung carcinoma.