However, in this study we reveal that the biology associated with disease relapse within stroma-rich tumours (and which are uniformly elevated for TGF-β signalling) is not associated with the biology that distinguishes between stroma-rich and epithelial-rich subtypes, nor is it associated with factors that are prognostic in general across unstratified stage II/III CC cohorts. This evidence concerns the gene TGFB1 and neoplasm.