We next confirmed that stratification of HiFi patients using a median split of the HPS was sufficient to represent the same elevated interferon (IFN) alpha and IFN gamma response GSEA signatures (figure 2D), however HPS was not associated with the levels of TGF-β signalling in HiFi tumours (online supplemental figure 2G). This evidence concerns the gene TGFB1 and neoplasm.