APP and neoplasm: Furthermore, to complement this transcriptional signalling, and to validate the utility of the in silico measure of APP, we next performed in vitro phenotypic measurements of antigen processing, using a fluorescent-labelled ova protein (DQ-ova) in the RAW264.7 macrophage model, cocultured with tumour-conditioned primary mesenchymal stromal cells to represent the stromal environment of a HiFi tumour microenvironment (TME) (figure 6F).