PSME1 and neoplasm: Cox survival analysis, followed by a multivariate model for each individual gene (to adjust for age, gender, pT stage, tumour location, tumour differentiation grade, lymphovascular invasion status and mucinous/non-mucinous subtype) filtered this list to seven LEA genes (p<0.05; table 1); namely FGL2, PSME1, SP110, WARS, CCND2, CCND3, PNPT1, which we term hereafter as a HiFi-specific prognostic signature (HPS) capable of distinguishing relapse from non-relapse (figure 2C; right).