Assessment of previously defined CAF subtypes developed in CC and pancreatic cancer22–24 failed to discriminate HiFi tumours based on relapse (online supplemental figure 2C); CRC CAF-A and CAF-B (upper left), pancreatic myCAF and iCAF (upper right), CRC differential contractility (lower left) and inflammatory-related fibroblasts CD34-THY1+, CD34-THY1- and CD34+ CAF (lower right)). The gene discussed is CD34; the disease is colorectal carcinoma.