TGFB1 and neoplasm: In addition, assessment of the same signals observed in HiFi versus LoFi human tumours (figure 1G, (online supplemental figure 4E) revealed an analogous pattern of enrichment in HiFi-related signalling cascades such as EMT, myogenesis and TGF-β signalling in HiFi/CMS4 GEMMs when compared with LoFi GEMMs (figure 7D).