STAT1 and neoplasm: Furthermore, stratification of an additional independent cohort of stage II/III colon patients (Clinical Proteomic Tumour Analysis Consortium, CPTAC)28 into HiFi and LoFi using our fibroblast score, followed by sub-stratification using the HPS, validated a significant enrichment for total STAT1 gene and protein expression in HiFi patients with high HPS expression (figure 3D; t-test p=0.0024 and p=0.018).