Activation of these same cascades were noted in a recent pancreatic cancer study as a downstream consequence of increased expression of endogenous retroviral transcripts.51 In our study, we highlighted the essential nature of functional STAT1 in regulating this potential viral mimicry signalling in specific immune lineages and in the APP phenotype associated with improved outcome in HiFi tumours. The gene discussed is STAT1; the disease is pancreatic neoplasm.