We had previously demonstrated that HG-SOC progression also requires the integration of ET-1 signaling with the transcriptional co-activators of the Hippo pathway, Yes-associated protein (YAP) and PDZ-binding domain (TAZ) [14, 15], those were instrumental for tumour initiation and progression in multiple tissue types [16, 17]. The gene discussed is YAP1; the disease is neoplasm.