Numerous serum biomarkers are used for diagnosing HCC, including α-fetoprotein (AFP), lipocalin 2 (LCN2), osteopontin (OPN), des-γ-carboxy prothrombin (DCP), and a fucosylated AFP glycoprotein variant (AFP-L3) [6–8]. This evidence concerns the gene SPP1 and hepatocellular carcinoma.