Selective stimulation of Abca1 with an ABCA1 agonist in mice expressing human APOE ε4, increased lipidation of ApoE ε4 and ameliorated ApoE ε4-driven cognitive impairments and brain pathology, rendering it to a similar level as the mice expressing ApoE ε3 [64]. This evidence concerns the gene APOE and Cognitive impairment.