ISG15, SNCA, RIPK2, PLCG2, RHOU, TRIB2 and ELP2 influenced the OS and PFI of ovarian cancer patients in the TCGA-OV dataset, while RIPK2 also affected the OS and PFI of ovarian cancer patients treated with Taxol in the GSE30161, GSE32062 and GSE63885 datasets. This evidence concerns the gene ISG15 and ovarian cancer.