To explore the underlying mechanism of TLNC1-mediated tumor progression and metastasis of liver cancer, we performed RNA-seq to identify the genes regulated by knockdown of TLNC1 and identified 4250 up-regulated and 2997 down-regulated genes (adjusted p < 0.05) in TLNC1 knockdown HCCLM3 cells compared with controls (Fig. 4a). The gene discussed is LINC01134; the disease is liver cancer.