To verify that TLNC1 could regulate p53 signaling pathway in human hepatoma, we detected the expression levels of p21 mRNA and found that the mRNA levels of p21 were negatively correlated with the expression levels of TLNC1 (r = − 0.6249, p < 0.0001) (Fig. S8). Here, TP53 is linked to hepatocellular carcinoma.