As immune cells infiltrating the tumor coexpress CD39 and CD73 in association with other coinhibitory molecules (e.g., CTLA4 and PD-L1), dual blockade of both CD39 and CD73 has been proposed with the aim of controlling the immunosuppressive role of adenosine signaling while minimizing the side effects of ICB [22, 220, 241–243]. This evidence concerns the gene ENTPD1 and neoplasm.