Regression analysis indicated a significant correlation between WASF2 expression and the methylation of five CpG sites (cg20745431, cg16406658, cg03436453, cg00307483, and cg24162579; Additional file 2: Fig. S8C), among which cg24162579 was significantly hypomethylated in the tumor samples of 44 matched pairs of patients with HCC from TCGA_LIHC (Additional file 2: Fig. S8D). This evidence concerns the gene WASF2 and neoplasm.