WASF2 suppression decreased HCC cell growth, migration, and invasion, by inducing G2/M phase cell cycle arrest and HCC cell death, inhibiting EMT, and hindering actin polymerization; cg24162579 methylation is a key epigenetic mechanism that regulates WASF2 expression and regulates prognosis, suggesting that WASF2 could be a potential therapeutic target for HCC. The gene discussed is WASF2; the disease is hepatocellular carcinoma.