This study aimed to investigate the drug resistance mechanism of GDC-0941 in breast cancer by constructing a mouse model and using a variety of breast cancer cells in vitro, to elaborate the negative feedback mechanism of GDC-0941 on ILK, and to investigate the effect of the combination of GDC-0941 and ILK inhibitors on the treatment of breast cancer. This evidence concerns the gene ILK and breast carcinoma.