Omicron encodes >30 mutations in Spike and has been reported to evade neutralization by sera from individuals receiving two doses of a COVID-19 vaccine (Cele et al., 2021; Garcia-Beltran et al., 2022; Gruell et al., 2022; Wu et al., 2022) as well as many SARS-CoV-2-specific monoclonal antibodies (Cameroni et al., 2021; Cao et al., 2021; Planas et al., 2021; VanBlargan et al., 2022). Here, CHMP5 is linked to COVID-19.