SOD1 and amyotrophic lateral sclerosis: An example of the latter is the role of a mucus-associated gut bacterium, Akkermansia muciniphila, in producing nicotinamide that can ameliorate neurodegeneration in a transgenic mouse model (Sod1-Tg) of amyotrophic lateral sclerosis (ALS), with supporting evidence coming from microbiome and metabolite measurements in individuals with ALS and asymptomatic members of the same household (Blacher et al., 2019).