CCN5 and cystic fibrosis: Furthermore, we showed that CCN5 can reverse pre-established CF, in which two mechanisms are thought to be involved: 1) CCN5 induces apoptosis in myofibroblasts (MyoFBs) but not in fibroblasts (FBs) and cardiomyocytes (CMs); and 2) CCN5 induces reverse trans-differentiation of MyoFBs to FBs [11].