In the static model the presence of LGD, aberrant expression of p53 and SOX2 were associated with an increased risk of neoplastic progression (HR LGD 3.57, p<0.01, HR p53 6.63, p<0.01; HR SOX2 2.20, p = 0.04) and the presence of esophagitis (HR 3.38, p<0.01). The gene discussed is TP53; the disease is esophagitis.