Huang Hai et al.49reported that eukaryotic initiation factor 3 subunit d (EIF3D) could interact with glucose regulated protein 78 (GRP78) and inhibit its degradation, further activating the unfolded protein response (UPR) signaling pathways and maintaining endoplasmic reticulum stress (ERS) homeostasis, thus promoting sunitinib resistance in RCC. The gene discussed is HSPA5; the disease is renal cell carcinoma.