MYOG and cerebrotendinous xanthomatosis: When CHIR was injected into the TA muscle treated with AAV-shOptn after CTX injury, the small size of eMYHC+ regenerating fibers at day 5 postinjury was efficiently rescued (Fig 7A and 7B), with concurrent restoration of eMYHC, MYOG and nuclear β-catenin levels (Fig 7C–7F).