OPTN and Duchenne muscular dystrophy: To explore the potential regulators of myogenesis, we performed bioinformatics screen from 5 myogenesis-related microarray datasets and identified optineurin (Optn) as one of the 5 overlapping genes, up-regulated during myoblast differentiation and muscle regeneration, while down-regulated in Duchenne muscular dystrophy (DMD) patients and mdx mice.