PLOD1 and Anxiety: To examine whether the activation of LH-projecting adBNST neurons ameliorated chronic pain–induced anxiety-like behavior, we bilaterally injected the retrograde-transported AAV2-expressing Cre recombinase into the LH, and AAV5 Cre-dependently expressing hM3Dq-mCherry into the adBNST (Fig. 4, A and B).