HMOX1 and myocardial ischemia: For myocardial ischemia/reperfusion injury and cardiomyopathy it induced, the mTOR pathway may protect cardiomyocytes against ferroptosis because of the reduction of ROS production (Baba et al. 2018), and Icariin attenuates ferroptosis by activating the Nrf2/HO-1 signaling pathway (Liu et al. 2021).